The incident came three days after militants bombed two other schools, one in Peshawar and the other in the Bajaur tribal region.
‘A girls' high school was blown up early Thursday morning in Shin Warsak town,’ 13 kilometres west of Wana, the main town in South Waziristan tribal region, local government official Allah Bagh Khan said.
He added that there was no loss of life in the explosion but it completely destroyed the school building.
Militants have destroyed hundreds of schools, mostly for girls, in Pakistan's northwest and its troubled tribal regions during the past couple of years.
At least 200 girls' schools in the northwest Swat valley were bombed during a two-year Taliban campaign to enforce sharia law.
The army, which is wrapping up a two-month campaign in Swat, has said it is poised to launch an assault into the tribal areas along the Afghan border to track down senior Taliban leaders, including Mehsud.
In the region Thursday morning, the military fired artillery at Taliban hideouts in Spinkai Raghzai and Sararogha villages of South Waziristan, a security official said